Qualified success was defined as: achieving a post intervention IOP 21 mmHg with medication and/or were in the need for further surgical interventions were considered as “failed”. Results In the current study, NPDS was performed to 213 eyes of 158 patients with or without cataract extraction from January 2005 to September 2010 at the King Abdul Aziz University Hospital (KAUH). After data management, 6 eyes of 5 patients were excluded from this cohort and the analysis was eventually performed to 197 eyes of 153 patients. Patients were in the mean age of 44.9 (±20.2) years, and an equivalent male to female ratio (76; 49.7% to 77; 50.3% respectively). The majority of cases were unilateral (109; 71.2%) presenting with moderate mean (±SD) level of IOP (25.5 (±10.2)) mmHg under a mean number of antiglaucoma medications (2.9 (±0.9)) and within a mean cup to disk ratio of 0.8 (±0.2). Previous ocular surgeries were done to 13; 6.6%. Combined NPDS/phacoemulsification procedures were done to 34 (17.3%) of them, while, the most prevalently used implant was SK-Gel in 59 Alpelisib order (29.9%) eyes and the operated eyes were followed up to a mean (±SD) follow up duration of 25.4 (±22.3) months. Details on demographic and clinical indices at presentation are demonstrated in Table 1. Table 1 Sample distributed by demographic and clinical data at presentation. Out of the 197 eyes, nearly one-forth (48 eyes; 24.4%) of 43 patients needed LGP. Within this specific group of patients, the mean (±SD) age was 34.9 (±18.4) years, mean preoperative IOP was 28.8 (±12.3) mmHg, CDR: 0.7 (±0.3) and anti-glaucoma medications: 3.3 (±0.8). The majority of such glaucoma cases were diagnosed as: uveitic OAG (21; 43.8%) followed by primary OAG (15; 31.3%), juvenile (5; 10.2%), Pseudo-exfoliation (2; 4.2%), Steroid induced (2; 4.2%), in addition to a single case (2.1%) of each of the following diagnoses; angle recession, normal tension and combined mechanism glaucoma. Previous ocular surgeries were done in 6 (12.5%) cases. The majority of surgeries were done with SK-Gel implant (18; 37.5%), while combined NPDS/phaco procedure was done in 2 (4.2%) eyes). LGP was performed as the initiative procedure if the target IOP was not achieved after excluding adherence of the iris to the TDMW. The mean duration between conduct of NPDS and the need for Nd:YAG LGP was 9.78 (± 11.16) months while these cases were followed up for mean follow-up of 16.7 (±16) ranging from 3 to 48 months after the LGP. Prior to LGP, the Mean IOP was 23.3 (±5.9) mmHg which significantly decreased to 14.6 (±4.4) mmHg at the last follow-up after the procedure (p < 0.001), and, the mean number of anti-glaucoma medications has significantly decreased from a pre LGP value of 3.3 (±0.8) to post LGP value of 0.54 (±0.9); p < 0.001. At the last follow up visit, Nd:YAG LGP was successful in controlling the IOP in 27 eyes (56.